A series of recent experimental results have overturned my long-standing thinking: “Using different isotopes and different modes to get the same results, it can be considered that elements have no mass spectrum interference.”
Although the abundances of different isotopes are different, the specific mass spectrum interferences received are also different, but there are cases where the proportions of the mass spectrum interferences are the same.
As shown in the figure, the results obtained by ammonia in-situ 80/80, oxygen transfer 78/94, and 80/96 are very similar. But after optimizing the reaction gas flow and setting the appropriate aerosol dilution ratio, a data close to the standard value was obtained!
To thoroughly understand chemical resolution, we not only require us to know the changes of the elements to be measured in the reaction cell, but also to know all the possible interferences in the unknown matrix and all the changes in the specific matrix!